The following Mega Millions and Powerball jackpots made the Major 10 biggest lottery jackpots in U.S. history, as of Jan. 21, 2023. The Powerball drawing on March 30, 2005, made 110 second-prize winners. The total payout to these winners was $19.4 million, with 89 winners getting $one hundred,000 every, when the other 21 winners received $500,000